• Describe the circulatory system as a system of blood vessels with a pump and valves to ensure one-way flow of blood
• Describe the single circulation of a fish
• Describe the double circulation of a mammal
• Explain the advantages of a double circulation
• Name and identify the structures of the mammalian heart, limited to the muscular wall, the septum, the left and right ventricles and atria, one-way valves and coronary arteries
• State that blood is pumped away from the heart into arteries and returns to the heart in veins
• State that the activity of the heart may be monitored by ECG, pulse rate and listening to sounds of valves closing
• Investigate and state the effect of physical activity on the pulse rate
• Describe coronary heart disease in terms of the blockage of coronary arteries and state the possible risk factors as diet, stress, smoking, genetic predisposition, age and gender
• Name and identify the atrioventricular and semilunar valves in the mammalian heart
• Explain the relative thickness:
– of the muscle wall of the left and right ventricles
– of the muscle wall of the atria compared to that of the ventricles
• Explain the importance of the septum in separating oxygenated and deoxygenated blood
• Describe the functioning of the heart in terms of the contraction of muscles of the atria and ventricles and the action of the valves
• Explain the effect of physical activity on the heart rate
• Discuss the roles of diet and exercise in the prevention of coronary heart disease
• Describe ways in which coronary heart disease may be treated, limited to drug treatment with aspirin and surgery (stents, angioplasty and by- pass)
• Describe the structure and functions of arteries, veins and capillaries
• Name the main blood vessels to and from the:
– heart, limited to vena cava, aorta, pulmonary artery and pulmonary vein
– lungs, limited to the pulmonary artery and pulmonary vein
– kidney, limited to the renal artery and renal vein
• Explain how the structures of arteries, veins and capillaries are adapted for their functions
• State the function of arterioles, venules and shunt vessels
• Outline the lymphatic system in terms of lymphatic vessels and lymph nodes
• Describe the function of the lymphatic system in the circulation of body fluids and the protection of the body from infection
• List the components of blood as red blood cells, white blood cells, platelets and plasma
• Identify red and white blood cells, as seen under the light microscope, on prepared slides and in diagrams and photomicrographs
• State the functions of the following components of blood:
– red blood cells in transporting oxygen, including the role of haemoglobin – white blood cells in phagocytosis and antibody production
– platelets in clotting (details are not required)
– plasma in the transport of blood cells, ions, soluble nutrients, hormones and carbon dioxide
• Identify lymphocyte and phagocyte white blood cells, as seen under the light microscope, on prepared slides and in diagrams and photomicrographs
• State the functions of:
– lymphocytes – antibody production
– phagocytes – phagocytosis
• Describe the process of clotting as the conversion of fibrinogen to fibrin to form a mesh
• State the roles of blood clotting as preventing blood loss and preventing the entry of pathogens
• Describe the transfer of materials between capillaries and tissue fluid (details of the roles of water potential and hydrostatic pressure are not required)