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Essential idea: The structure of DNA is ideally suited to its function.
Essential idea: The structure of DNA is ideally suited to its function.
From reactive bases that bond easily with their complements to the nucleoside tri-phosphates that can with them the energy to bond and build a strand of DNA. The structure of DNA is ideally suited to replicating itself and storing information.
Understanding
Understanding
Nucleosomes help to supercoil the DNA.
DNA structure suggested a mechanism for DNA replication.
DNA polymerases can only add nucleotides to the 3’ end of a primer.
DNA replication is continuous on the leading strand and discontinuous on the lagging strand. [Details of DNA replication differ between prokaryotes and eukaryotes. Only the prokaryotic system is expected.]
DNA replication is carried out by a complex system of enzymes. [The proteins and enzymes involved in DNA replication should include helicase, DNA gyrase, single strand binding proteins, DNA primase and DNA polymerases I and III.]
Some regions of DNA do not code for proteins but have other important functions. [The regions of DNA that do not code for proteins should be limited to regulators of gene expression, introns, telomeres and genes for tRNAs.]
Application
Application
Rosalind Franklin’s and Maurice Wilkins’ investigation of DNA structure by X-ray diffraction.
Use of nucleotides containing dideoxyribonucleic acid to stop DNA replication in preparation of samples for base sequencing.
Tandem repeats are used in DNA profiling.
Skill
Skill
Analysis of results of the Hershey and Chase experiment providing evidence that DNA is the genetic material.
Utilization of molecular visualization software to analyse the association between protein and DNA within a nucleosome.
7.1 - DNA Structure.pdf7.2 - DNA Replication.pdfPage updated
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